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The anti-inflammatory pathways are primarily mediated by the farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 (TGR5) 147

27 Remarkably, rapid ascent to 4500 or 5500 m significantly increases HAPE incidence compared with slow ascent (0.2% versus 7% or 2.5% versus 15.5%, respectively), with a recurrence risk of ~60% under rapid ascent conditions

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Larger trials would provide more precise effect estimates and detect smaller differences between groups

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Similar findings were also observed in neuron-specific GCL knockdown mouse by Fernandez-Fernandez et al